Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control

The aim of this study was to assess the diagnostic accuracy of dual-source computed tomography (DSCT) for evaluation of coronary artery disease (CAD) in a population with extensive coronary calcifications without heart rate control. Thirty patients (24 male, 6 female, mean age 63.1±11.3 years) with...

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Main Authors:	Scheffel, Hans, Alkadhi, Hatem, Plass, André, Vachenauer, Robert, Desbiolles, Lotus, Gaemperli, Oliver, Schepis, Tiziano, Frauenfelder, Thomas, Schertler, Thomas, Husmann, Lars, Grunenfelder, Jürg, Genoni, Michele, Kaufmann, Philipp A., Marincek, Borut, Leschka, Sebastian
Format:	Online
Language:	English
Published:	Springer-Verlag 2006
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705545/

id	pubmed-1705545
recordtype	oai_dc
spelling	pubmed-17055452006-12-18 Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control Scheffel, Hans Alkadhi, Hatem Plass, André Vachenauer, Robert Desbiolles, Lotus Gaemperli, Oliver Schepis, Tiziano Frauenfelder, Thomas Schertler, Thomas Husmann, Lars Grunenfelder, Jürg Genoni, Michele Kaufmann, Philipp A. Marincek, Borut Leschka, Sebastian Cardiac The aim of this study was to assess the diagnostic accuracy of dual-source computed tomography (DSCT) for evaluation of coronary artery disease (CAD) in a population with extensive coronary calcifications without heart rate control. Thirty patients (24 male, 6 female, mean age 63.1±11.3 years) with a high pre-test probability of CAD underwent DSCT coronary angiography and invasive coronary angiography (ICA) within 14±9 days. No beta-blockers were administered prior to the scan. Two readers independently assessed image quality of all coronary segments with a diameter ≥1.5 mm using a four-point score (1: excellent to 4: not assessable) and qualitatively assessed significant stenoses as narrowing of the luminal diameter >50%. Causes of false-positive (FP) and false-negative (FN) ratings were assigned to calcifications or motion artifacts. ICA was considered the standard of reference. Mean body mass index was 28.3±3.9 kg/m2 (range 22.4–36.3 kg/m2), mean heart rate during CT was 70.3±14.2 bpm (range 47–102 bpm), and mean Agatston score was 821±904 (range 0–3,110). Image quality was diagnostic (scores 1–3) in 98.6% (414/420) of segments (mean image quality score 1.68±0.75); six segments in three patients were considered not assessable (1.4%). DSCT correctly identified 54 of 56 significant coronary stenoses. Severe calcifications accounted for false ratings in nine segments (eight FP/one FN) and motion artifacts in two segments (one FP/one FN). Overall sensitivity, specificity, positive and negative predictive value for evaluating CAD were 96.4, 97.5, 85.7, and 99.4%, respectively. First experience indicates that DSCT coronary angiography provides high diagnostic accuracy for assessment of CAD in a high pre-test probability population with extensive coronary calcifications and without heart rate control. Springer-Verlag 2006-09-19 2006-12 /pmc/articles/PMC1705545/ /pubmed/17031451 http://dx.doi.org/10.1007/s00330-006-0474-0 Text en © Springer-Verlag 2006
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Scheffel, Hans Alkadhi, Hatem Plass, André Vachenauer, Robert Desbiolles, Lotus Gaemperli, Oliver Schepis, Tiziano Frauenfelder, Thomas Schertler, Thomas Husmann, Lars Grunenfelder, Jürg Genoni, Michele Kaufmann, Philipp A. Marincek, Borut Leschka, Sebastian
spellingShingle	Scheffel, Hans Alkadhi, Hatem Plass, André Vachenauer, Robert Desbiolles, Lotus Gaemperli, Oliver Schepis, Tiziano Frauenfelder, Thomas Schertler, Thomas Husmann, Lars Grunenfelder, Jürg Genoni, Michele Kaufmann, Philipp A. Marincek, Borut Leschka, Sebastian Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
author_facet	Scheffel, Hans Alkadhi, Hatem Plass, André Vachenauer, Robert Desbiolles, Lotus Gaemperli, Oliver Schepis, Tiziano Frauenfelder, Thomas Schertler, Thomas Husmann, Lars Grunenfelder, Jürg Genoni, Michele Kaufmann, Philipp A. Marincek, Borut Leschka, Sebastian
author_sort	Scheffel, Hans
title	Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
title_short	Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
title_full	Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
title_fullStr	Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
title_full_unstemmed	Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control
title_sort	accuracy of dual-source ct coronary angiography: first experience in a high pre-test probability population without heart rate control
description	The aim of this study was to assess the diagnostic accuracy of dual-source computed tomography (DSCT) for evaluation of coronary artery disease (CAD) in a population with extensive coronary calcifications without heart rate control. Thirty patients (24 male, 6 female, mean age 63.1±11.3 years) with a high pre-test probability of CAD underwent DSCT coronary angiography and invasive coronary angiography (ICA) within 14±9 days. No beta-blockers were administered prior to the scan. Two readers independently assessed image quality of all coronary segments with a diameter ≥1.5 mm using a four-point score (1: excellent to 4: not assessable) and qualitatively assessed significant stenoses as narrowing of the luminal diameter >50%. Causes of false-positive (FP) and false-negative (FN) ratings were assigned to calcifications or motion artifacts. ICA was considered the standard of reference. Mean body mass index was 28.3±3.9 kg/m2 (range 22.4–36.3 kg/m2), mean heart rate during CT was 70.3±14.2 bpm (range 47–102 bpm), and mean Agatston score was 821±904 (range 0–3,110). Image quality was diagnostic (scores 1–3) in 98.6% (414/420) of segments (mean image quality score 1.68±0.75); six segments in three patients were considered not assessable (1.4%). DSCT correctly identified 54 of 56 significant coronary stenoses. Severe calcifications accounted for false ratings in nine segments (eight FP/one FN) and motion artifacts in two segments (one FP/one FN). Overall sensitivity, specificity, positive and negative predictive value for evaluating CAD were 96.4, 97.5, 85.7, and 99.4%, respectively. First experience indicates that DSCT coronary angiography provides high diagnostic accuracy for assessment of CAD in a high pre-test probability population with extensive coronary calcifications and without heart rate control.
publisher	Springer-Verlag
publishDate	2006
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705545/
_version_	1611392104124121088

Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate control

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