N-hydroxylation of carcinogenic and mutagenic aromatic amines.

N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole)...

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Bibliographic Details
Main Authors: Kato, R, Kamataki, T, Yamazoe, Y
Format: Online
Language:English
Published: 1983
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569125/