Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.
cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in nucleated peripheral blood cells (buffy coat cells) of testicular and ovarian cancer patients receivi...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1985
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568668/ |