Free-radical production and oxidative reactions of hemoglobin.
Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contr...
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| Format: | Online |
| Language: | English |
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1985
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568600/ |
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pubmed-1568600 |
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pubmed-15686002006-09-18 Free-radical production and oxidative reactions of hemoglobin. Winterbourn, C C Research Article Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions of various protective agents, are considered. 1985-12 /pmc/articles/PMC1568600/ /pubmed/3007097 Text en |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Winterbourn, C C |
| spellingShingle |
Winterbourn, C C Free-radical production and oxidative reactions of hemoglobin. |
| author_facet |
Winterbourn, C C |
| author_sort |
Winterbourn, C C |
| title |
Free-radical production and oxidative reactions of hemoglobin. |
| title_short |
Free-radical production and oxidative reactions of hemoglobin. |
| title_full |
Free-radical production and oxidative reactions of hemoglobin. |
| title_fullStr |
Free-radical production and oxidative reactions of hemoglobin. |
| title_full_unstemmed |
Free-radical production and oxidative reactions of hemoglobin. |
| title_sort |
free-radical production and oxidative reactions of hemoglobin. |
| description |
Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions of various protective agents, are considered. |
| publishDate |
1985 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568600/ |
| _version_ |
1611388761476694016 |