Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.

A case is made for the involvement of pituitary prostaglandins (PGs) in the regulation of thyrotropin (TSH) secretion by citing recent evidence that TSH release in vivo and in vitro is enhanced by treatment with exogenous PGs and is inhibited by drugs (e.g., indomethacin) that block PG synthesis. Ph...

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Main Authors:	Wright, K C, Hedge, G A
Format:	Online
Language:	English
Published:	1981
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568437/

id	pubmed-1568437
recordtype	oai_dc
spelling	pubmed-15684372006-09-19 Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion. Wright, K C Hedge, G A Research Article A case is made for the involvement of pituitary prostaglandins (PGs) in the regulation of thyrotropin (TSH) secretion by citing recent evidence that TSH release in vivo and in vitro is enhanced by treatment with exogenous PGs and is inhibited by drugs (e.g., indomethacin) that block PG synthesis. Pharmacological studies were then performed to test the hypothesis that hypothalamic PGs also affect TSH secretion indirectly via the appropriate hypothalamic hormones that regulate pituitary secretion. The inhibition of thyroidectomy-induced TSH secretion was used as an endpoint in choosing the best of several drugs purported to inhibit PG synthesis. The established effectiveness of indomethacin and aspirin were used for reference in testing the following drugs: naproxen, mefenamic acid, tranylcypromine, and phenelzine. Only naproxen was found to be effective, but since it was no more potent than indomethacin, the latter drug was used for subsequent work. Indomethacin was stereotaxically implanted into several hypothalamic regions known to regulate TSH secretion, and sequential plasma samples were analyzed for TSH by radioimmunoassay. Bilateral implants of indomethacin in the anterior hypothalamic area increased TSH secretion throughout the 72 hr period of study. Sham inplants at this site and indomethacin implants in other nearby sites were ineffective. These findings suggest that endogenous PGs play an inhibitory role in the hypothalamic regulation of pituitary secretion. 1981-04 /pmc/articles/PMC1568437/ /pubmed/7238449 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wright, K C Hedge, G A
spellingShingle	Wright, K C Hedge, G A Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
author_facet	Wright, K C Hedge, G A
author_sort	Wright, K C
title	Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
title_short	Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
title_full	Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
title_fullStr	Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
title_full_unstemmed	Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
title_sort	pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.
description	A case is made for the involvement of pituitary prostaglandins (PGs) in the regulation of thyrotropin (TSH) secretion by citing recent evidence that TSH release in vivo and in vitro is enhanced by treatment with exogenous PGs and is inhibited by drugs (e.g., indomethacin) that block PG synthesis. Pharmacological studies were then performed to test the hypothesis that hypothalamic PGs also affect TSH secretion indirectly via the appropriate hypothalamic hormones that regulate pituitary secretion. The inhibition of thyroidectomy-induced TSH secretion was used as an endpoint in choosing the best of several drugs purported to inhibit PG synthesis. The established effectiveness of indomethacin and aspirin were used for reference in testing the following drugs: naproxen, mefenamic acid, tranylcypromine, and phenelzine. Only naproxen was found to be effective, but since it was no more potent than indomethacin, the latter drug was used for subsequent work. Indomethacin was stereotaxically implanted into several hypothalamic regions known to regulate TSH secretion, and sequential plasma samples were analyzed for TSH by radioimmunoassay. Bilateral implants of indomethacin in the anterior hypothalamic area increased TSH secretion throughout the 72 hr period of study. Sham inplants at this site and indomethacin implants in other nearby sites were ineffective. These findings suggest that endogenous PGs play an inhibitory role in the hypothalamic regulation of pituitary secretion.
publishDate	1981
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568437/
_version_	1611388672192544768

Pharmacological studies of the involvement of hypothalamic prostaglandins in the regulation of thyrotropin secretion.

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