Current status of the Gene-Tox Program.

The U.S. Environmental Protection Agency's Gene-Tox Program is a multiphased effort to review and evaluate the existing literature in assay systems available in the field of genetic toxicology. The first phase of the Gene-Tox Program selected assay systems for evaluation, generated expert panel...

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Main Authors:	Auletta, A E, Brown, M, Wassom, J S, Cimino, M C
Format:	Online
Language:	English
Published:	1991
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568261/

id	pubmed-1568261
recordtype	oai_dc
spelling	pubmed-15682612006-09-18 Current status of the Gene-Tox Program. Auletta, A E Brown, M Wassom, J S Cimino, M C Research Article The U.S. Environmental Protection Agency's Gene-Tox Program is a multiphased effort to review and evaluate the existing literature in assay systems available in the field of genetic toxicology. The first phase of the Gene-Tox Program selected assay systems for evaluation, generated expert panel reviews of the data from the scientific literature, and recommended testing protocols for the systems. Phase II established and evaluated the database of chemical genetic toxicity data for its relevance to identifying human health hazards. The ongoing phase III continues reviewing and updating chemical data in selected assay systems. Currently, data exist on over 4000 chemicals in 27 assay systems; two additional assay systems will be included in phase III. The review data are published in the scientific literature and are also publicly available through the National Library of Medicine TOXNET system. The review and analysis components of Gene-Tox comprise 45 published papers, and several others are in preparation. Differences that have been observed between Gene-Tox and National Toxicology Program databases relative to the sensitivity, specificity, accuracy, and predictivity of genetic toxicity data compared to carcinogenesis data are ascribable to differences between the two databases in chemical selection criteria, testing protocols, and chemical class distributions. 1991-12 /pmc/articles/PMC1568261/ /pubmed/1820273 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Auletta, A E Brown, M Wassom, J S Cimino, M C
spellingShingle	Auletta, A E Brown, M Wassom, J S Cimino, M C Current status of the Gene-Tox Program.
author_facet	Auletta, A E Brown, M Wassom, J S Cimino, M C
author_sort	Auletta, A E
title	Current status of the Gene-Tox Program.
title_short	Current status of the Gene-Tox Program.
title_full	Current status of the Gene-Tox Program.
title_fullStr	Current status of the Gene-Tox Program.
title_full_unstemmed	Current status of the Gene-Tox Program.
title_sort	current status of the gene-tox program.
description	The U.S. Environmental Protection Agency's Gene-Tox Program is a multiphased effort to review and evaluate the existing literature in assay systems available in the field of genetic toxicology. The first phase of the Gene-Tox Program selected assay systems for evaluation, generated expert panel reviews of the data from the scientific literature, and recommended testing protocols for the systems. Phase II established and evaluated the database of chemical genetic toxicity data for its relevance to identifying human health hazards. The ongoing phase III continues reviewing and updating chemical data in selected assay systems. Currently, data exist on over 4000 chemicals in 27 assay systems; two additional assay systems will be included in phase III. The review data are published in the scientific literature and are also publicly available through the National Library of Medicine TOXNET system. The review and analysis components of Gene-Tox comprise 45 published papers, and several others are in preparation. Differences that have been observed between Gene-Tox and National Toxicology Program databases relative to the sensitivity, specificity, accuracy, and predictivity of genetic toxicity data compared to carcinogenesis data are ascribable to differences between the two databases in chemical selection criteria, testing protocols, and chemical class distributions.
publishDate	1991
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1568261/
_version_	1611388576525713408

Current status of the Gene-Tox Program.

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