Inhalation toxicology and carcinogenicity of 1,3-butadiene in B6C3F1 mice following 65 weeks of exposure.

1,3-Butadiene, a large-production volume chemical used mainly in the manufacture of synthetic rubber, was found to induce multiple-organ carcinogenicity in male and female B6C3F1 mice at exposure concentrations (625 and 1250 ppm) equivalent to and below the OSHA standard of 1000 ppm. Since this stud...

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Bibliographic Details
Main Authors: Melnick, R L, Huff, J E, Roycroft, J H, Chou, B J, Miller, R A
Format: Online
Language:English
Published: 1990
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567751/