In vitro and in vivo studies on the degradation of metallothionein.

Degradation of metallothionein (MT) from rat liver was examined. Degradation of apo-MT by liver homogenate was greater than that by cytosol. At pH 5.5, degradation by homogenate was more than that at pH 7.2. These findings suggest that proteases that function at acidic pH are probably involved in MT...

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Bibliographic Details
Main Authors: Klaassen, C D, Choudhuri, S, McKim, J M, Lehman-McKeeman, L D, Kershaw, W C
Format: Online
Language:English
Published: 1994
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567434/