Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1.

Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1, and VCAM-1.

We compared the effects of treatment with methylprednisolone or the 21-aminosteroids, U-74389 and U-74006F (Tirilizad mesylate), on hyperoxic lung injury and the associated expression of mRNA for several adhesion molecules in rats. Inhalation of > 95% oxygen for up to 72 hr in Sprague-Dawley rats...

Full description

Bibliographic Details
Main Authors: Griffin, R L, Krzesicki, R F, Fidler, S F, Rosenbloom, C L, Auchampach, J A, Manning, A M, Haas, J V, Cammarata, S K, Chin, J E, Richards, I M
Format: Online
Language:English
Published: 1994
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567004/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567004/

Similar Items