Stochastic mRNA Synthesis in Mammalian Cells

Individual cells in genetically homogeneous populations have been found to express different numbers of molecules of specific proteins. We investigated the origins of these variations in mammalian cells by counting individual molecules of mRNA produced from a reporter gene that was stably integrated...

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Bibliographic Details
Main Authors: Raj, Arjun, Peskin, Charles S, Tranchina, Daniel, Vargas, Diana Y, Tyagi, Sanjay
Format: Online
Language:English
Published: Public Library of Science 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1563489/