Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.
Flavone and isoflavone phytoestrogens are plant chemicals and are known to be competitive inhibitors of cytochrome P450 aromatase with respect to the androgen substrate. Aromatase is the enzyme that converts androgen to estrogen; therefore, these plant chemicals are thought to be capable of modifyin...
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1998
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533021/ |