Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.

The aim of this study was to examine the serum levels of insulin and some adrenal steroid hormones in men chronically exposed to low doses of trichloroethylene (TCE). A total of 85 workers participated in this study. Each worker had urine collected and analyzed for trichloroacetic acids (UTCA) on th...

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Main Authors:	Goh, V H, Chia, S E, Ong, C N
Format:	Online
Language:	English
Published:	1998
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1532938/

id	pubmed-1532938
recordtype	oai_dc
spelling	pubmed-15329382006-08-08 Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men. Goh, V H Chia, S E Ong, C N Research Article The aim of this study was to examine the serum levels of insulin and some adrenal steroid hormones in men chronically exposed to low doses of trichloroethylene (TCE). A total of 85 workers participated in this study. Each worker had urine collected and analyzed for trichloroacetic acids (UTCA) on the same day that a blood sample was taken for analyses of serum testosterone, sex hormone-binding globulin (SHBG), androstenedione, cortisol, aldosterone, and insulin. The mean concentration of environmental TCE was 29.6 ppm and the mean UTCA was 22.4 mg/g creatinine (range 0.8-136.4). TCE exposure did not cause any significant changes to the adrenal steroid hormone productions. The results showed that UTCA was significantly correlated to serum insulin levels. Insulin and SHBG responded in tandem, with the highest levels found in workers exposed to TCE for less than 2 years; levels of both parameters were significantly lowered in those exposed for more than 2 years. A triphasic response in insulin levels to TCE, which depended on the duration of exposure, was noted. Initial exposure caused an acute rise in insulin levels. This was followed by a fall to normal levels in those exposed 2-4 years and then a slight rise in those exposed for more than 6 years. The mechanism for this pattern of response to TCE exposure is yet unknown. 1998-01 /pmc/articles/PMC1532938/ /pubmed/9417767 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Goh, V H Chia, S E Ong, C N
spellingShingle	Goh, V H Chia, S E Ong, C N Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
author_facet	Goh, V H Chia, S E Ong, C N
author_sort	Goh, V H
title	Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
title_short	Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
title_full	Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
title_fullStr	Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
title_full_unstemmed	Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
title_sort	effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.
description	The aim of this study was to examine the serum levels of insulin and some adrenal steroid hormones in men chronically exposed to low doses of trichloroethylene (TCE). A total of 85 workers participated in this study. Each worker had urine collected and analyzed for trichloroacetic acids (UTCA) on the same day that a blood sample was taken for analyses of serum testosterone, sex hormone-binding globulin (SHBG), androstenedione, cortisol, aldosterone, and insulin. The mean concentration of environmental TCE was 29.6 ppm and the mean UTCA was 22.4 mg/g creatinine (range 0.8-136.4). TCE exposure did not cause any significant changes to the adrenal steroid hormone productions. The results showed that UTCA was significantly correlated to serum insulin levels. Insulin and SHBG responded in tandem, with the highest levels found in workers exposed to TCE for less than 2 years; levels of both parameters were significantly lowered in those exposed for more than 2 years. A triphasic response in insulin levels to TCE, which depended on the duration of exposure, was noted. Initial exposure caused an acute rise in insulin levels. This was followed by a fall to normal levels in those exposed 2-4 years and then a slight rise in those exposed for more than 6 years. The mechanism for this pattern of response to TCE exposure is yet unknown.
publishDate	1998
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1532938/
_version_	1611385940005093376

Effects of chronic exposure to low doses of trichloroethylene on steroid hormone and insulin levels in normal men.

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