Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium

This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, repre...

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Main Authors: Thijs, Lutgarde, Staessen, Jan, Amery, Antoon, Bruaux, Pierre, Buchet, Jean-Pierre, Claeys, FranÇoise, De Plaen, Pierre, Ducoffre, Geneviève, Lauwerys, Robert, Lijnen, Paul, Nick, Laurence, Remy, Annie Saint, Roels, Harry, Rondia, Désiré, Sartor, Francis
Format: Online
Language:English
Published: 1992
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519594/
id pubmed-1519594
recordtype oai_dc
spelling pubmed-15195942006-07-26 Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium Thijs, Lutgarde Staessen, Jan Amery, Antoon Bruaux, Pierre Buchet, Jean-Pierre Claeys, FranÇoise De Plaen, Pierre Ducoffre, Geneviève Lauwerys, Robert Lijnen, Paul Nick, Laurence Remy, Annie Saint Roels, Harry Rondia, Désiré Sartor, Francis Contributed Articles This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 μmole/L, range 6.5–23.0 μmole/L) than in women (12.6 μmole/L, range 6.3–23.2 μmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = −0.10) and urinary cadmium (r = −0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = −0.11), log γ-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = −0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis. 1992-11 /pmc/articles/PMC1519594/ /pubmed/1486857 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
spellingShingle Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
author_facet Thijs, Lutgarde
Staessen, Jan
Amery, Antoon
Bruaux, Pierre
Buchet, Jean-Pierre
Claeys, FranÇoise
De Plaen, Pierre
Ducoffre, Geneviève
Lauwerys, Robert
Lijnen, Paul
Nick, Laurence
Remy, Annie Saint
Roels, Harry
Rondia, Désiré
Sartor, Francis
author_sort Thijs, Lutgarde
title Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_short Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_full Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_fullStr Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_full_unstemmed Determinants of serum zinc in a random population sample of four Belgian towns with different degrees of environmental exposure to cadmium
title_sort determinants of serum zinc in a random population sample of four belgian towns with different degrees of environmental exposure to cadmium
description This report investigated the distribution of serum zinc and the factors determining serum zinc concentration in a large random population sample. The 1977 participants (959 men and 1018 women), 20–80 years old, constituted a stratified random sample of the population of four Belgian districts, representing two areas with low and two with high environmental exposure to cadmium. For each exposure level, a rural and an urban area were selected. The serum concentration of zinc, frequently used as an index for zinc status in human subjects, was higher in men (13.1 μmole/L, range 6.5–23.0 μmole/L) than in women (12.6 μmole/L, range 6.3–23.2 μmole/L). In men, 20% of the variance of serum zinc was explained by age (linear and squared term, R = 0.29), diurnal variation (r = 0.29), and total cholesterol (r = 0.16). After adjustment for these covariates, a negative relationship was observed between serum zinc and both blood (r = −0.10) and urinary cadmium (r = −0.14). In women, 11% of the variance could be explained by age (linear and squared term, R = 0.15), diurnal variation in serum zinc (r = 0.27), creatinine clearance (r = −0.11), log γ-glutamyltranspeptidase (r = 0.08), cholesterol (r = 0.07), contraceptive pill intake (r = −0.07), and log serum ferritin (r = 0.06). Before and after adjustment for significant covariates, serum zinc was, on average, lowest in the two districts where the body burden of cadmium, as assessed by urinary cadmium excretion, was highest. These results were not altered when subjects exposed to heavy metals at work were excluded from analysis.
publishDate 1992
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519594/
_version_ 1611385257715564544

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