Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.

Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.

Murine pulmonary alveolar macrophages (PAM) form macrophage colonies in vitro with colony-stimulating factors, which stimulate the clonal growth of radioresistant alveolar colony-forming cells (AL-CFC). The toxic effects of fibrogenic mineral dust particles on AL-CFC were investigated after intratra...

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Main Authors: Oghiso, Y, Yamada, Y, Shibata, Y
Format: Online
Language:English
Published: 1992
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519553/
id pubmed-1519553
recordtype oai_dc
spelling pubmed-15195532006-07-26 Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages. Oghiso, Y Yamada, Y Shibata, Y Research Article Murine pulmonary alveolar macrophages (PAM) form macrophage colonies in vitro with colony-stimulating factors, which stimulate the clonal growth of radioresistant alveolar colony-forming cells (AL-CFC). The toxic effects of fibrogenic mineral dust particles on AL-CFC were investigated after intratracheal instillation into mice. Exposure to either crocidolite asbestos or silica (Min-u-sil) induced a significant depletion of AL-CFC as well as a decrease in PAM recovery compared to either untreated or titanium dioxide-exposed animals. Such effects were also noted with different doses (50-200 micrograms/animal) of instilled particles. The plating efficiency of AL-CFC was depleted in PAM exposed to fibrogenic particles in vitro, but not when exposed to nonfibrogenic titanium dioxide particles. These results indicate the toxic effects of fibrogenic dust particles on the clonal growth of PAM, cells which play a role in the clearance of inhaled particles from the lung and in subsequent pathologic processes. 1992-07 /pmc/articles/PMC1519553/ /pubmed/1327734 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Oghiso, Y
Yamada, Y
Shibata, Y
spellingShingle Oghiso, Y
Yamada, Y
Shibata, Y
Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
author_facet Oghiso, Y
Yamada, Y
Shibata, Y
author_sort Oghiso, Y
title Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
title_short Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
title_full Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
title_fullStr Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
title_full_unstemmed Effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
title_sort effects of instilled fibrogenic particles on the clonal growth of murine pulmonary alveolar macrophages.
description Murine pulmonary alveolar macrophages (PAM) form macrophage colonies in vitro with colony-stimulating factors, which stimulate the clonal growth of radioresistant alveolar colony-forming cells (AL-CFC). The toxic effects of fibrogenic mineral dust particles on AL-CFC were investigated after intratracheal instillation into mice. Exposure to either crocidolite asbestos or silica (Min-u-sil) induced a significant depletion of AL-CFC as well as a decrease in PAM recovery compared to either untreated or titanium dioxide-exposed animals. Such effects were also noted with different doses (50-200 micrograms/animal) of instilled particles. The plating efficiency of AL-CFC was depleted in PAM exposed to fibrogenic particles in vitro, but not when exposed to nonfibrogenic titanium dioxide particles. These results indicate the toxic effects of fibrogenic dust particles on the clonal growth of PAM, cells which play a role in the clearance of inhaled particles from the lung and in subsequent pathologic processes.
publishDate 1992
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519553/
_version_ 1611385237120483328

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