Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.

Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were...

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Main Authors:	Gonsebatt, M E, Salazar, A M, Montero, R, Díaz Barriga, F, Yáñez, L, Gómez, H, Ostrosky-Wegman, P
Format:	Online
Language:	English
Published:	1995
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519331/

id	pubmed-1519331
recordtype	oai_dc
spelling	pubmed-15193312006-07-28 Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico. Gonsebatt, M E Salazar, A M Montero, R Díaz Barriga, F Yáñez, L Gómez, H Ostrosky-Wegman, P Research Article Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments. 1995-02 /pmc/articles/PMC1519331/ /pubmed/7621789 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gonsebatt, M E Salazar, A M Montero, R Díaz Barriga, F Yáñez, L Gómez, H Ostrosky-Wegman, P
spellingShingle	Gonsebatt, M E Salazar, A M Montero, R Díaz Barriga, F Yáñez, L Gómez, H Ostrosky-Wegman, P Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
author_facet	Gonsebatt, M E Salazar, A M Montero, R Díaz Barriga, F Yáñez, L Gómez, H Ostrosky-Wegman, P
author_sort	Gonsebatt, M E
title	Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
title_short	Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
title_full	Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
title_fullStr	Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
title_full_unstemmed	Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
title_sort	genotoxic monitoring of workers at a hazardous waste disposal site in mexico.
description	Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.
publishDate	1995
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1519331/
_version_	1611385115550679040

Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.

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