Checkpoint control of mitotic exit—do budding yeast mind the GAP?
Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activit...
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| Format: | Online |
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The Rockefeller University Press
2006
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513541/ |
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pubmed-15135412007-11-29 Checkpoint control of mitotic exit—do budding yeast mind the GAP? Cooper, John A. Nelson, Scott A. Reviews Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1. The Rockefeller University Press 2006-01-30 /pmc/articles/PMC1513541/ /pubmed/16431930 http://dx.doi.org/10.1083/jcb.200512153 Text en Copyright © 2006, The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Cooper, John A. Nelson, Scott A. |
| spellingShingle |
Cooper, John A. Nelson, Scott A. Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| author_facet |
Cooper, John A. Nelson, Scott A. |
| author_sort |
Cooper, John A. |
| title |
Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| title_short |
Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| title_full |
Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| title_fullStr |
Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| title_full_unstemmed |
Checkpoint control of mitotic exit—do budding yeast mind the GAP? |
| title_sort |
checkpoint control of mitotic exit—do budding yeast mind the gap? |
| description |
Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1. |
| publisher |
The Rockefeller University Press |
| publishDate |
2006 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513541/ |
| _version_ |
1611384804497948672 |