Metabolic aspects of pyrolysis mutagens in food.
The first step in metabolic activation of mutagenic and carcinogenic heterocyclic amines has been elucidated to be N-hydroxylation by cytochrome P-448. N-Hydroxyamino compounds are further activated to form N-O-acyl derivatives that readily react with DNA. The adducts between the metabolites of Trp-...
| Main Authors: | , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1986
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474417/ |