Lipopolysaccharide-induced hepatic injury is enhanced by polychlorinated biphenyls.
After intravenous administration of bacterial lipopolysaccharide (LPS) to rats, polymorphonuclear neutrophils (PMNs) rapidly accumulate in the liver, and midzonal hepatic necrosis is prominent by 6 hr. PMNs are required for the development of hepatic injury in rats. Certain polychlorinated biphenyls...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
1996
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1469377/ |