Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound

Chemical Genetics Reveals an RGS/G-Protein Role in the Action of a Compound

We report here on a chemical genetic screen designed to address the mechanism of action of a small molecule. Small molecules that were active in models of urinary incontinence were tested on the nematode Caenorhabditis elegans, and the resulting phenotypes were used as readouts in a genetic screen t...

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Bibliographic Details
Main Authors: Fitzgerald, Kevin, Tertyshnikova, Svetlana, Moore, Lisa, Bjerke, Lynn, Burley, Ben, Cao, Jian, Carroll, Pamela, Choy, Robert, Doberstein, Steve, Dubaquie, Yves, Franke, Yvonne, Kopczynski, Jenny, Korswagen, Hendrik, Krystek, Stanley R, Lodge, Nicholas J, Plasterk, Ronald, Starrett, John, Stouch, Terry, Thalody, George, Wayne, Honey, van der Linden, Alexander, Zhang, Yongmei, Walker, Stephen G, Cockett, Mark, Wardwell-Swanson, Judi, Ross-Macdonald, Petra, Kindt, Rachel M
Format: Online
Language:English
Published: Public Library of Science 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1440875/

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