Lactate as a marker of energy failure in critically ill patients: hypothesis

Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match i...

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Main Authors:	Valenza, Franco, Aletti, Gabriele, Fossali, Tommaso, Chevallard, Giorgio, Sacconi, Francesca, Irace, Manuela, Gattinoni, Luciano
Format:	Online
Language:	English
Published:	BioMed Central 2005
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414013/

id	pubmed-1414013
recordtype	oai_dc
spelling	pubmed-14140132006-03-28 Lactate as a marker of energy failure in critically ill patients: hypothesis Valenza, Franco Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano Review Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state. BioMed Central 2005 2005-09-28 /pmc/articles/PMC1414013/ /pubmed/16356243 http://dx.doi.org/10.1186/cc3818 Text en Copyright © 2005 BioMed Central Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Valenza, Franco Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano
spellingShingle	Valenza, Franco Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano Lactate as a marker of energy failure in critically ill patients: hypothesis
author_facet	Valenza, Franco Aletti, Gabriele Fossali, Tommaso Chevallard, Giorgio Sacconi, Francesca Irace, Manuela Gattinoni, Luciano
author_sort	Valenza, Franco
title	Lactate as a marker of energy failure in critically ill patients: hypothesis
title_short	Lactate as a marker of energy failure in critically ill patients: hypothesis
title_full	Lactate as a marker of energy failure in critically ill patients: hypothesis
title_fullStr	Lactate as a marker of energy failure in critically ill patients: hypothesis
title_full_unstemmed	Lactate as a marker of energy failure in critically ill patients: hypothesis
title_sort	lactate as a marker of energy failure in critically ill patients: hypothesis
description	Lactate measurement in the critically ill has been traditionally used to stratify patients with poor outcome. However, plasma lactate levels are the result of a finely tuned interplay of factors that affect the balance between its production and its clearance. When the oxygen supply does not match its consumption, organisms such as man who are forced to produce ATP for their integrity adapt in many different ways up to the point when energy failure occurs. Lactate, being part of the adaptive response, may then be used to assess the severity of the supply/demand imbalance. In such a scenario, the time to intervention becomes relevant: early and effective treatment may allow the cell to revert to a normal state, as long as the oxygen machinery (i.e. mithocondria) is intact. Conversely, once the mithocondria are deranged, energy failure occurs even in the presence of normoxia. The lactate increase in critically ill patients may therefore be viewed as an early marker of a potentially reversible state.
publisher	BioMed Central
publishDate	2005
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414013/
_version_	1611381470376493056

Lactate as a marker of energy failure in critically ill patients: hypothesis

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