High incidence of rapid telomere loss in telomerase-deficient Caenorhabditis elegans

Telomerase is essential to maintain telomere length in most eukaryotes. Other functions for telomerase have been proposed but molecular mechanisms remain unclear. We studied Caenorhabditis elegans with a mutation in the trt-1 telomerase reverse transcriptase gene. Mutant animals showed a progressive...

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Bibliographic Details
Main Authors: Cheung, Iris, Schertzer, Michael, Rose, Ann, Lansdorp, Peter M.
Format: Online
Language:English
Published: Oxford University Press 2006
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326242/