Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments

Comparison of the Use of a Physiologically Based Pharmacokinetic Model and a Classical Pharmacokinetic Model for Dioxin Exposure Assessments

In epidemiologic studies, exposure assessments of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) assume a fixed elimination rate. Recent data suggest a dose-dependent elimination rate for TCDD. A physiologically based pharmacokinetic (PBPK) model, which uses a body-burden–dependent elimination rate, was...

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Bibliographic Details
Main Authors: Emond, Claude, Michalek, Joel E., Birnbaum, Linda S., DeVito, Michael J.
Format: Online
Language:English
Published: National Institute of Environmental Health Sciences 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314902/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314902/

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