Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.

Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.

Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with patholo...

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Main Authors: Zhang, J, Jiang, S, Watson, R R
Format: Online
Language:English
Published: 2001
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242076/
id pubmed-1242076
recordtype oai_dc
spelling pubmed-12420762005-11-08 Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice. Zhang, J Jiang, S Watson, R R Research Article Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with pathology in cardiovascular disease and conditions that have an inflammatory base. Exposure to SSCS through a burning cigarette for 30 min/day, 5 days a week, for 4 months increased interleukin-6 production in spleen and lipid peroxide level in mouse liver. Our findings suggest that ROS induced by SSCS will promote hepatic lipid peroxidation and may also contribute to an increase in interleukin-6 cytokine production. Multiple antioxidants given as a dietary supplement significantly normalized interleukin-6 cytokine production and prevented hepatic lipid peroxidation. We conclude that the SSCS in moderate intake levels increased oxidation and promoted inflammatory cytokine interleukin-6 production, whereas antioxidants prevented these changes. 2001-10 /pmc/articles/PMC1242076/ /pubmed/11675265 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Zhang, J
Jiang, S
Watson, R R
spellingShingle Zhang, J
Jiang, S
Watson, R R
Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
author_facet Zhang, J
Jiang, S
Watson, R R
author_sort Zhang, J
title Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
title_short Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
title_full Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
title_fullStr Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
title_full_unstemmed Antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
title_sort antioxidant supplementation prevents oxidation and inflammatory responses induced by sidestream cigarette smoke in old mice.
description Sidestream cigarette smoke (SSCS) makes up about 85% of significantly toxic environmental tobacco smoke (ETS). Reactive oxygen species (ROS) in SSCS play an important role in the pathogenesis of a wide range of diseases. Interleukin-6 is a pro-inflammatory cytokine and is closely linked with pathology in cardiovascular disease and conditions that have an inflammatory base. Exposure to SSCS through a burning cigarette for 30 min/day, 5 days a week, for 4 months increased interleukin-6 production in spleen and lipid peroxide level in mouse liver. Our findings suggest that ROS induced by SSCS will promote hepatic lipid peroxidation and may also contribute to an increase in interleukin-6 cytokine production. Multiple antioxidants given as a dietary supplement significantly normalized interleukin-6 cytokine production and prevented hepatic lipid peroxidation. We conclude that the SSCS in moderate intake levels increased oxidation and promoted inflammatory cytokine interleukin-6 production, whereas antioxidants prevented these changes.
publishDate 2001
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242076/
_version_ 1611378145864187904

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