Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
Polychlorinated biphenyls (PCBs) are a family of persistent organic contaminants suspected to cause adverse effects in wildlife and humans. In rodents, PCBs bind to the aryl hydrocarbon (AhR) and pregnane X receptors (PXR) inducing the expression of catabolic cytochrome p450 enzymes of the CYP1A and...
| Main Authors: | , , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
2004
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241825/ |