Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.

Perinatal exposure to Dutch "background" dioxin levels in 1990 was high, but comparable with that of other industrialized Western European countries. Exposure during the sensitive perinatal period may cause permanent disturbances. Therefore, we assessed the health status and various hemato...

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Main Authors:	ten Tusscher, Gavin W, Steerenberg, Peter A, van Loveren, Henk, Vos, Joseph G, von dem Borne, Albert E G K, Westra, Matthijs, van der Slikke, Johannes W, Olie, Kees, Pluim, Hendrik J, Koppe, Janna G
Format:	Online
Language:	English
Published:	2003
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241656/

id	pubmed-1241656
recordtype	oai_dc
spelling	pubmed-12416562005-11-08 Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure. ten Tusscher, Gavin W Steerenberg, Peter A van Loveren, Henk Vos, Joseph G von dem Borne, Albert E G K Westra, Matthijs van der Slikke, Johannes W Olie, Kees Pluim, Hendrik J Koppe, Janna G Research Article Perinatal exposure to Dutch "background" dioxin levels in 1990 was high, but comparable with that of other industrialized Western European countries. Exposure during the sensitive perinatal period may cause permanent disturbances. Therefore, we assessed the health status and various hematologic and immunologic parameters among our longitudinal cohort. A medical history was taken and venipuncture performed in a longitudinal cohort of 27 healthy 8-year-old children who had documented perinatal dioxin exposure. Linear regression revealed a decrease in allergy in relation to prenatal (p = 0.02) and postnatal (p = 0.03) dioxin exposure. Increases in CD4+ T-helper cells (p = 0.006) and in CD45RA+ cells (p = 0.02) were seen in relation to postnatal exposure. A persistently decreased platelet count (p = 0.04) and increased thrombopoietin concentration (p = 0.03) were seen in relation to postnatal exposure. This follow-up has shown a decrease in allergy, persistently decreased thrombocytes, increased thrombopoietin, and increased CD4+ T-helper and increased CD45RA+ cell counts. This study provides indications of effects at the stem cell level of perinatal dioxin exposure, persisting until minimally 8 years after birth. 2003-09 /pmc/articles/PMC1241656/ /pubmed/12948893 Text en
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	ten Tusscher, Gavin W Steerenberg, Peter A van Loveren, Henk Vos, Joseph G von dem Borne, Albert E G K Westra, Matthijs van der Slikke, Johannes W Olie, Kees Pluim, Hendrik J Koppe, Janna G
spellingShingle	ten Tusscher, Gavin W Steerenberg, Peter A van Loveren, Henk Vos, Joseph G von dem Borne, Albert E G K Westra, Matthijs van der Slikke, Johannes W Olie, Kees Pluim, Hendrik J Koppe, Janna G Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
author_facet	ten Tusscher, Gavin W Steerenberg, Peter A van Loveren, Henk Vos, Joseph G von dem Borne, Albert E G K Westra, Matthijs van der Slikke, Johannes W Olie, Kees Pluim, Hendrik J Koppe, Janna G
author_sort	ten Tusscher, Gavin W
title	Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
title_short	Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
title_full	Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
title_fullStr	Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
title_full_unstemmed	Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.
title_sort	persistent hematologic and immunologic disturbances in 8-year-old dutch children associated with perinatal dioxin exposure.
description	Perinatal exposure to Dutch "background" dioxin levels in 1990 was high, but comparable with that of other industrialized Western European countries. Exposure during the sensitive perinatal period may cause permanent disturbances. Therefore, we assessed the health status and various hematologic and immunologic parameters among our longitudinal cohort. A medical history was taken and venipuncture performed in a longitudinal cohort of 27 healthy 8-year-old children who had documented perinatal dioxin exposure. Linear regression revealed a decrease in allergy in relation to prenatal (p = 0.02) and postnatal (p = 0.03) dioxin exposure. Increases in CD4+ T-helper cells (p = 0.006) and in CD45RA+ cells (p = 0.02) were seen in relation to postnatal exposure. A persistently decreased platelet count (p = 0.04) and increased thrombopoietin concentration (p = 0.03) were seen in relation to postnatal exposure. This follow-up has shown a decrease in allergy, persistently decreased thrombocytes, increased thrombopoietin, and increased CD4+ T-helper and increased CD45RA+ cell counts. This study provides indications of effects at the stem cell level of perinatal dioxin exposure, persisting until minimally 8 years after birth.
publishDate	2003
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241656/
_version_	1611377890191998976

Persistent hematologic and immunologic disturbances in 8-year-old Dutch children associated with perinatal dioxin exposure.

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