High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.

High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.

Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women parti...

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Main Authors: Petreas, Myrto, She, Jianwen, Brown, F Reber, Winkler, Jennifer, Windham, Gayle, Rogers, Evan, Zhao, Guomao, Bhatia, Rajiv, Charles, M Judith
Format: Online
Language:English
Published: 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241571/
id pubmed-1241571
recordtype oai_dc
spelling pubmed-12415712005-11-08 High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women. Petreas, Myrto She, Jianwen Brown, F Reber Winkler, Jennifer Windham, Gayle Rogers, Evan Zhao, Guomao Bhatia, Rajiv Charles, M Judith Research Article Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n = 32) were analyzed by low-resolution mass spectrometry in negative-ion chemical ionization mode, whereas serum samples (n = 50) were analyzed by dual-column gas chromatography with electron capture detection. The results confirmed our earlier findings. Concentrations of 2,2,4,4 -tetrabromodiphenyl ether (BDE-47) in contemporary California women ranged between 5 and 510 ng/g lipid, with a median (16.5 ng/g lipid) 3-10 times higher than those reported from Europe. In contrast, PBDEs were not measurable in any of 420 archived serum samples collected in the 1960s from San Francisco Bay Area women participating in a study of child development. BDE-47 concentrations did not increase with age or with concentrations of a polychlorinated biphenyl (PCB-153), suggesting other routes of exposure in addition to diet. Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat. 2003-07 /pmc/articles/PMC1241571/ /pubmed/12842770 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Petreas, Myrto
She, Jianwen
Brown, F Reber
Winkler, Jennifer
Windham, Gayle
Rogers, Evan
Zhao, Guomao
Bhatia, Rajiv
Charles, M Judith
spellingShingle Petreas, Myrto
She, Jianwen
Brown, F Reber
Winkler, Jennifer
Windham, Gayle
Rogers, Evan
Zhao, Guomao
Bhatia, Rajiv
Charles, M Judith
High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
author_facet Petreas, Myrto
She, Jianwen
Brown, F Reber
Winkler, Jennifer
Windham, Gayle
Rogers, Evan
Zhao, Guomao
Bhatia, Rajiv
Charles, M Judith
author_sort Petreas, Myrto
title High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
title_short High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
title_full High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
title_fullStr High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
title_full_unstemmed High body burdens of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) in California women.
title_sort high body burdens of 2,2',4,4'-tetrabromodiphenyl ether (bde-47) in california women.
description Following our first report on elevated polybrominated diphenyl ether (PBDE) concentrations in California women, we expanded our investigation to include diverse groups of local women. We analyzed additional adipose and serum samples collected in the late 1990s from San Francisco Bay Area women participating in a breast cancer study and in a reproductive study, respectively. Adipose samples (n = 32) were analyzed by low-resolution mass spectrometry in negative-ion chemical ionization mode, whereas serum samples (n = 50) were analyzed by dual-column gas chromatography with electron capture detection. The results confirmed our earlier findings. Concentrations of 2,2,4,4 -tetrabromodiphenyl ether (BDE-47) in contemporary California women ranged between 5 and 510 ng/g lipid, with a median (16.5 ng/g lipid) 3-10 times higher than those reported from Europe. In contrast, PBDEs were not measurable in any of 420 archived serum samples collected in the 1960s from San Francisco Bay Area women participating in a study of child development. BDE-47 concentrations did not increase with age or with concentrations of a polychlorinated biphenyl (PCB-153), suggesting other routes of exposure in addition to diet. Rising body burdens of endocrine-disrupting chemicals such as PBDEs may pose a potential public health threat.
publishDate 2003
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241571/
_version_ 1611377835402854400

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