Cancer risks in naval divers with multiple exposures to carcinogens.

Cancer risks in naval divers with multiple exposures to carcinogens.

We investigated risks for cancer and the case for a cause-effect relationship in five successive cohorts of naval commando divers (n = 682) with prolonged underwater exposures (skin, gastrointestinal tract, and airways) to many toxic compounds in the Kishon River, Israel's most polluted waterwa...

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Main Authors: Richter, Elihu D, Friedman, Lee S, Tamir, Yuval, Berman, Tamar, Levy, Or, Westin, Jerome B, Peretz, Tamar
Format: Online
Language:English
Published: 2003
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241453/
id pubmed-1241453
recordtype oai_dc
spelling pubmed-12414532005-11-08 Cancer risks in naval divers with multiple exposures to carcinogens. Richter, Elihu D Friedman, Lee S Tamir, Yuval Berman, Tamar Levy, Or Westin, Jerome B Peretz, Tamar Research Article We investigated risks for cancer and the case for a cause-effect relationship in five successive cohorts of naval commando divers (n = 682) with prolonged underwater exposures (skin, gastrointestinal tract, and airways) to many toxic compounds in the Kishon River, Israel's most polluted waterway, from 1948 to 1995. Releases of industrial, ship, and agricultural effluents in the river increased substantially, fish yields decreased, and toxic damage to marine organisms increased. Among the divers (16,343 person-years follow-up from 18 years of age to year 2000), the observed/expected ratio for all tumors was 2.29 (p<0.01). Risks increased in cohorts first diving after 1960 compared to risks in earlier cohorts, notably for hematolymphopoietic, central nervous system, gastrointestinal, and skin cancer; induction periods were often brief. The findings suggest that the increases in risk for cancer and short induction periods resulted from direct contact with and absorption of multiple toxic compounds. Early toxic effects in marine life predicted later risks for cancer in divers. 2003-04 /pmc/articles/PMC1241453/ /pubmed/12676624 Text en
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Richter, Elihu D
Friedman, Lee S
Tamir, Yuval
Berman, Tamar
Levy, Or
Westin, Jerome B
Peretz, Tamar
spellingShingle Richter, Elihu D
Friedman, Lee S
Tamir, Yuval
Berman, Tamar
Levy, Or
Westin, Jerome B
Peretz, Tamar
Cancer risks in naval divers with multiple exposures to carcinogens.
author_facet Richter, Elihu D
Friedman, Lee S
Tamir, Yuval
Berman, Tamar
Levy, Or
Westin, Jerome B
Peretz, Tamar
author_sort Richter, Elihu D
title Cancer risks in naval divers with multiple exposures to carcinogens.
title_short Cancer risks in naval divers with multiple exposures to carcinogens.
title_full Cancer risks in naval divers with multiple exposures to carcinogens.
title_fullStr Cancer risks in naval divers with multiple exposures to carcinogens.
title_full_unstemmed Cancer risks in naval divers with multiple exposures to carcinogens.
title_sort cancer risks in naval divers with multiple exposures to carcinogens.
description We investigated risks for cancer and the case for a cause-effect relationship in five successive cohorts of naval commando divers (n = 682) with prolonged underwater exposures (skin, gastrointestinal tract, and airways) to many toxic compounds in the Kishon River, Israel's most polluted waterway, from 1948 to 1995. Releases of industrial, ship, and agricultural effluents in the river increased substantially, fish yields decreased, and toxic damage to marine organisms increased. Among the divers (16,343 person-years follow-up from 18 years of age to year 2000), the observed/expected ratio for all tumors was 2.29 (p<0.01). Risks increased in cohorts first diving after 1960 compared to risks in earlier cohorts, notably for hematolymphopoietic, central nervous system, gastrointestinal, and skin cancer; induction periods were often brief. The findings suggest that the increases in risk for cancer and short induction periods resulted from direct contact with and absorption of multiple toxic compounds. Early toxic effects in marine life predicted later risks for cancer in divers.
publishDate 2003
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241453/
_version_ 1611377759365365760

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