Functional Coverage of the Human Genome by Existing Structures, Structural Genomics Targets, and Homology Models

The bias in protein structure and function space resulting from experimental limitations and targeting of particular functional classes of proteins by structural biologists has long been recognized, but never continuously quantified. Using the Enzyme Commission and the Gene Ontology classifications...

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Bibliographic Details
Main Authors: Xie, Lei, Bourne, Philip E
Format: Online
Language:English
Published: Public Library of Science 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1188274/