Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins

Prostaglandin E2 (PGE2) and prostaglandin I2 (PGI2) are major inflammatory mediators that play important roles in pain sensation and hyperalgesia. The role of their receptors (EP and IP, respectively) in inflammation has been well documented, although the EP receptor subtypes involved in this proces...

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Bibliographic Details
Main Authors: Moriyama, Tomoko, Higashi, Tomohiro, Togashi, Kazuya, Iida, Tohko, Segi, Eri, Sugimoto, Yukihiko, Tominaga, Tomoko, Narumiya, Shuh, Tominaga, Makoto
Format: Online
Language:English
Published: BioMed Central 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1074353/