Implications of continued upregulation of p16INK4a through the evolution from high-grade squamous intraepithelial lesion to invasive squamous carcinoma of the cervix
On integration into the host cervical keratinocyte genome, human papillomavirus (HPV) E7 protein binds pRB, releasing E2F from normally incompetent pRB-E2F complexes and allowing propagation of G1-S transition by the E2F. p16 INK4a, a tumour suppressor protein, increases in re?ex response to coun...
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| Format: | Journal |
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Malaysian Journal of Pathology, Academy of Medicine of Malaysia
2011
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| Online Access: | http://www.myjurnal.my/public/article-view.php?id=16982 |