Immune response of BALB/c mice against an experimental vaccine of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with BCG or Mycobacterium vaccae
<div align="justify">Immune response in BALB/c mice immunized 3 times with different doses (50 ?g or 200 ?g of protein) of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with either BCG (1 x107 CFU) or different doses of killed Mycobacterium vaccae (1 x106, 1 x107) wa...
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| Format: | Journal |
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Tropical Biomedicine, Malaysian Society of Parasitology and Tropical Medicine
2010
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| Online Access: | http://www.myjurnal.my/public/article-view.php?id=13721 |
| Summary: | <div align="justify">Immune response in BALB/c mice immunized 3 times with different doses (50 ?g or 200 ?g of protein) of Alum precipitated autoclaved Leishmania major (Alum-ALM) mixed with either BCG (1 x107 CFU) or different doses of killed Mycobacterium vaccae (1 x106, 1 x107) was assessed. Mice immunized with low dose of Alum-ALM mixed with either BCG or low M. vaccae showed a significantly higher IFN-? production and a lower IL-4 level and a significantly lower parasite burden compared to the control PBS injected group. It seems that immunization with a low dose of Alum-ALM mixed with an adjuvant induces a Th1 type of immune response in susceptible BALB/c mice.</div> |
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