Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution

Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternativ...

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Main Authors:	Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam
Format:	Article
Language:	English
Published:	Penerbit Universiti Kebangsaan Malaysia 2017
Online Access:	http://journalarticle.ukm.my/11723/ http://journalarticle.ukm.my/11723/ http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf

id	oai:generic.eprints.org:11723
recordtype	eprints
spelling	oai:generic.eprints.org:117232018-05-30T00:02:33Z http://journalarticle.ukm.my/11723/ Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam, Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data. Penerbit Universiti Kebangsaan Malaysia 2017-12 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf Thirunanthini Manoharan, and Jayanthi Arasan, and Habshah Midi, and Mohd Bakri Adam, (2017) Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution. Sains Malaysiana, 46 (12). pp. 2529-2539. ISSN 0126-6039 http://www.ukm.my/jsm/english_journals/vol46num12_2017/contentsVol46num12_2017.htm
repository_type	Digital Repository
institution_category	Local University
institution	Universiti Kebangasaan Malaysia
building	UKM Institutional Repository
collection	Online Access
language	English
description	Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data.
format	Article
author	Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam,
spellingShingle	Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam, Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
author_facet	Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam,
author_sort	Thirunanthini Manoharan,
title	Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_short	Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_full	Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_fullStr	Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_full_unstemmed	Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
title_sort	bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution
publisher	Penerbit Universiti Kebangsaan Malaysia
publishDate	2017
url	http://journalarticle.ukm.my/11723/ http://journalarticle.ukm.my/11723/ http://journalarticle.ukm.my/11723/1/31%20Thirunanthini.pdf
first_indexed	2018-09-07T10:46:27Z
last_indexed	2018-09-07T10:46:27Z
_version_	1610945331630964736

Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution

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