Stimuli-responsive prodrug chemistries for drug delivery

Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas of infection, neurodegeneration, and oncology. Advances have been made in treating these diverse pathologies but there still remain many challenging areas. Amongst the most difficult ar...

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Main Authors:	Taresco, Vincenzo, Alexander, Cameron, Singh, Nishant, Pearce, Amanda K.
Format:	Article
Language:	English
Published:	Wiley 2018
Online Access:	http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/1/Author%27s%20Copy-%20Before%20acceptance.pdf

id	nottingham-52656
recordtype	eprints
spelling	nottingham-526562018-07-04T10:45:07Z http://eprints.nottingham.ac.uk/52656/ Stimuli-responsive prodrug chemistries for drug delivery Taresco, Vincenzo Alexander, Cameron Singh, Nishant Pearce, Amanda K. Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas of infection, neurodegeneration, and oncology. Advances have been made in treating these diverse pathologies but there still remain many challenging areas. Amongst the most difficult are those involving highly potent and/or cytotoxic agents which present the inherent problem of adverse off-target effects. Of key importance is to widen the therapeutic window for such agents by reducing access to non-diseased cells and enhancing release at targeted sites. Spatiotemporal controlled release can be achieved by exploiting physical, chemical, or biological stimuli present at the specific diseased area. A crucial strategy involves drug-carrier linkages able to respond to physiological or biochemical stimuli present in the disease region, and there is now significant literature on (polymeric) prodrugs based on the drug + carrier + cleavable linker philosophy, predominantly for cancer applications. The authors therefore focus this mini-review primarily on single/multi stimuli-responsive prodrugs for cancer therapies, covering prominent examples of prodrug chemistries used to endow polymers with controlled and site-specific drug delivery properties. Additionally, the possibilities for exploiting similar approaches to disease-associated stimuli present in bacterial and viral infections, inflammatory and immune diseases, and in degenerative disorders are emphasized. Wiley 2018-06-21 Article PeerReviewed application/pdf en http://eprints.nottingham.ac.uk/52656/1/Author%27s%20Copy-%20Before%20acceptance.pdf Taresco, Vincenzo and Alexander, Cameron and Singh, Nishant and Pearce, Amanda K. (2018) Stimuli-responsive prodrug chemistries for drug delivery. Advanced Therapeutics . p. 1800030. ISSN 2366-3987 https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.201800030 doi:10.1002/adtp.201800030 doi:10.1002/adtp.201800030
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Research into advanced therapeutic materials is of growing importance worldwide, particularly in the disease areas of infection, neurodegeneration, and oncology. Advances have been made in treating these diverse pathologies but there still remain many challenging areas. Amongst the most difficult are those involving highly potent and/or cytotoxic agents which present the inherent problem of adverse off-target effects. Of key importance is to widen the therapeutic window for such agents by reducing access to non-diseased cells and enhancing release at targeted sites. Spatiotemporal controlled release can be achieved by exploiting physical, chemical, or biological stimuli present at the specific diseased area. A crucial strategy involves drug-carrier linkages able to respond to physiological or biochemical stimuli present in the disease region, and there is now significant literature on (polymeric) prodrugs based on the drug + carrier + cleavable linker philosophy, predominantly for cancer applications. The authors therefore focus this mini-review primarily on single/multi stimuli-responsive prodrugs for cancer therapies, covering prominent examples of prodrug chemistries used to endow polymers with controlled and site-specific drug delivery properties. Additionally, the possibilities for exploiting similar approaches to disease-associated stimuli present in bacterial and viral infections, inflammatory and immune diseases, and in degenerative disorders are emphasized.
format	Article
author	Taresco, Vincenzo Alexander, Cameron Singh, Nishant Pearce, Amanda K.
spellingShingle	Taresco, Vincenzo Alexander, Cameron Singh, Nishant Pearce, Amanda K. Stimuli-responsive prodrug chemistries for drug delivery
author_facet	Taresco, Vincenzo Alexander, Cameron Singh, Nishant Pearce, Amanda K.
author_sort	Taresco, Vincenzo
title	Stimuli-responsive prodrug chemistries for drug delivery
title_short	Stimuli-responsive prodrug chemistries for drug delivery
title_full	Stimuli-responsive prodrug chemistries for drug delivery
title_fullStr	Stimuli-responsive prodrug chemistries for drug delivery
title_full_unstemmed	Stimuli-responsive prodrug chemistries for drug delivery
title_sort	stimuli-responsive prodrug chemistries for drug delivery
publisher	Wiley
publishDate	2018
url	http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/ http://eprints.nottingham.ac.uk/52656/1/Author%27s%20Copy-%20Before%20acceptance.pdf
first_indexed	2018-09-06T14:28:35Z
last_indexed	2018-09-06T14:28:35Z
_version_	1610868709938692096

Stimuli-responsive prodrug chemistries for drug delivery

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