Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men

Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviving motor units via reinnervation of denervated fi...

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Main Authors:	Piasecki, M., Ireland, A., Piasecki, J., Stashuk, D.W., Swiecicka, A., Rutter, M.K., Jones, D.A., McPhee, J.S.
Format:	Article
Language:	English
Published:	Wiley 2018
Online Access:	http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/1/Piasecki_Failure%20to%20expand%20the%20motor%20unit%20size%20to%20compensate%20for%20declining%20motor%20unit%20numbers%20distinguishes%20sarcopenic%20from%20non-sarcopenic%20older%20men.pdf

id	nottingham-51831
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spelling	nottingham-518312018-05-17T18:10:42Z http://eprints.nottingham.ac.uk/51831/ Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men Piasecki, M. Ireland, A. Piasecki, J. Stashuk, D.W. Swiecicka, A. Rutter, M.K. Jones, D.A. McPhee, J.S. Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviving motor units via reinnervation of denervated fibres. However, no evidence exists to confirm the extent of motor unit remodelling in sarcopenic individuals. The aim of the present study was to compare motor unit size and number between young (n = 48), non‐sarcopenic old (n = 13), pre‐sarcopenic (n = 53) and sarcopenic (n = 29) men. Motor unit potentials (MUPs) were isolated from intramuscular and surface EMG recordings. The motor unit numbers were reduced in all groups of old compared with young men (all P < 0.001). MUPs were higher in non‐sarcopenic and pre‐sarcopenic men compared with young men (P = 0.039 and 0.001 respectively), but not in the vastus lateralis of sarcopenic old (P = 0.485). The results suggest that extensive motor unit remodelling occurs relatively early during ageing, exceeds the loss of muscle mass and precedes sarcopenia. Reinnervation of denervated muscle fibres probably expands the motor unit size in the non‐sarcopenic and pre‐sarcopenic old, but not in the sarcopenic old. These findings suggest that a failure to expand the motor unit size distinguishes sarcopenic from pre‐sarcopenic muscles. Wiley 2018-05-01 Article PeerReviewed application/pdf en cc_by http://eprints.nottingham.ac.uk/51831/1/Piasecki_Failure%20to%20expand%20the%20motor%20unit%20size%20to%20compensate%20for%20declining%20motor%20unit%20numbers%20distinguishes%20sarcopenic%20from%20non-sarcopenic%20older%20men.pdf Piasecki, M. and Ireland, A. and Piasecki, J. and Stashuk, D.W. and Swiecicka, A. and Rutter, M.K. and Jones, D.A. and McPhee, J.S. (2018) Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men. Journal of Physiology, 596 (9). pp. 1627-1637. ISSN 1469-7793 https://doi.org/10.1113/JP275520 doi:10.1113/JP275520 doi:10.1113/JP275520
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Sarcopenia results from the progressive loss of skeletal muscle mass and reduced function in older age. It is likely to be associated with the well‐documented reduction of motor unit numbers innervating limb muscles and the increase in size of surviving motor units via reinnervation of denervated fibres. However, no evidence exists to confirm the extent of motor unit remodelling in sarcopenic individuals. The aim of the present study was to compare motor unit size and number between young (n = 48), non‐sarcopenic old (n = 13), pre‐sarcopenic (n = 53) and sarcopenic (n = 29) men. Motor unit potentials (MUPs) were isolated from intramuscular and surface EMG recordings. The motor unit numbers were reduced in all groups of old compared with young men (all P < 0.001). MUPs were higher in non‐sarcopenic and pre‐sarcopenic men compared with young men (P = 0.039 and 0.001 respectively), but not in the vastus lateralis of sarcopenic old (P = 0.485). The results suggest that extensive motor unit remodelling occurs relatively early during ageing, exceeds the loss of muscle mass and precedes sarcopenia. Reinnervation of denervated muscle fibres probably expands the motor unit size in the non‐sarcopenic and pre‐sarcopenic old, but not in the sarcopenic old. These findings suggest that a failure to expand the motor unit size distinguishes sarcopenic from pre‐sarcopenic muscles.
format	Article
author	Piasecki, M. Ireland, A. Piasecki, J. Stashuk, D.W. Swiecicka, A. Rutter, M.K. Jones, D.A. McPhee, J.S.
spellingShingle	Piasecki, M. Ireland, A. Piasecki, J. Stashuk, D.W. Swiecicka, A. Rutter, M.K. Jones, D.A. McPhee, J.S. Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
author_facet	Piasecki, M. Ireland, A. Piasecki, J. Stashuk, D.W. Swiecicka, A. Rutter, M.K. Jones, D.A. McPhee, J.S.
author_sort	Piasecki, M.
title	Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
title_short	Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
title_full	Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
title_fullStr	Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
title_full_unstemmed	Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
title_sort	failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men
publisher	Wiley
publishDate	2018
url	http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/ http://eprints.nottingham.ac.uk/51831/1/Piasecki_Failure%20to%20expand%20the%20motor%20unit%20size%20to%20compensate%20for%20declining%20motor%20unit%20numbers%20distinguishes%20sarcopenic%20from%20non-sarcopenic%20older%20men.pdf
first_indexed	2018-09-06T14:23:13Z
last_indexed	2018-09-06T14:23:13Z
_version_	1610868371643957248

Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men

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