Human alpha defensin CNV haplotype diversity
Humans have highly variable number of alpha defensin genes, with between 3-16 diploid copies. Alpha-defensin genes have important roles in human innate immunity and diseases. Recently, GWAS studies reported this locus associated with IgA nephropathy and periodontitis. However, the underlying mechani...
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| Format: | Thesis (University of Nottingham only) |
| Language: | English |
| Published: |
2018
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| Online Access: | http://eprints.nottingham.ac.uk/51262/ http://eprints.nottingham.ac.uk/51262/1/PhD_thesis_complete_corrected.pdf |