Amygdala subnuclei response and connectivity during emotional processing

The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emoti...

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Main Authors:	Hrybouski, Stanislau, Aghamohammadi-Sereshki, Arash, Madan, Christopher R., Shafer, Andrea T., Baron, Corey A., Seres, Peter, Beaulieu, Christian, Olsen, Fraser, Malykhin, Nikolai V.
Format:	Article
Language:	English
Published:	Elsevier 2016
Online Access:	http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/1/High_RES_Amy_Manuscript.pdf

id	nottingham-49070
recordtype	eprints
spelling	nottingham-490702018-01-17T03:21:04Z http://eprints.nottingham.ac.uk/49070/ Amygdala subnuclei response and connectivity during emotional processing Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with event-related high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to the negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by the negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the centromedial amygdala was more connected with the nuclei of the basal amygdala than with the lateral amygdala. Current findings provide evidence of functional specialization within the human amygdala. Elsevier 2016-06-30 Article PeerReviewed application/pdf en cc_by_nc_nd http://eprints.nottingham.ac.uk/49070/1/High_RES_Amy_Manuscript.pdf Hrybouski, Stanislau and Aghamohammadi-Sereshki, Arash and Madan, Christopher R. and Shafer, Andrea T. and Baron, Corey A. and Seres, Peter and Beaulieu, Christian and Olsen, Fraser and Malykhin, Nikolai V. (2016) Amygdala subnuclei response and connectivity during emotional processing. NeuroImage, 133 . pp. 98-110. ISSN 1095-9572 http://www.sciencedirect.com/science/article/pii/S1053811916001658 doi:10.1016/j.neuroimage.2016.02.056 doi:10.1016/j.neuroimage.2016.02.056
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with event-related high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to the negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by the negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the centromedial amygdala was more connected with the nuclei of the basal amygdala than with the lateral amygdala. Current findings provide evidence of functional specialization within the human amygdala.
format	Article
author	Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V.
spellingShingle	Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V. Amygdala subnuclei response and connectivity during emotional processing
author_facet	Hrybouski, Stanislau Aghamohammadi-Sereshki, Arash Madan, Christopher R. Shafer, Andrea T. Baron, Corey A. Seres, Peter Beaulieu, Christian Olsen, Fraser Malykhin, Nikolai V.
author_sort	Hrybouski, Stanislau
title	Amygdala subnuclei response and connectivity during emotional processing
title_short	Amygdala subnuclei response and connectivity during emotional processing
title_full	Amygdala subnuclei response and connectivity during emotional processing
title_fullStr	Amygdala subnuclei response and connectivity during emotional processing
title_full_unstemmed	Amygdala subnuclei response and connectivity during emotional processing
title_sort	amygdala subnuclei response and connectivity during emotional processing
publisher	Elsevier
publishDate	2016
url	http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/ http://eprints.nottingham.ac.uk/49070/1/High_RES_Amy_Manuscript.pdf
first_indexed	2018-09-06T14:04:06Z
last_indexed	2018-09-06T14:04:06Z
_version_	1610867169505050624

Amygdala subnuclei response and connectivity during emotional processing

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