Engineering substrate promiscuity in halophilic alcohol dehydrogenase (HvADH2) by in silico design
An alcohol dehydrogenase from the halophilic archaeon Haloferax volcanii (HvADH2) has been engineered by rational design to broaden its substrate scope towards the conversion of a range of aromatic substrates, including flurbiprofenol, that is an intermediate of the non-steroidal anti-inflammatory d...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2017
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| Online Access: | http://eprints.nottingham.ac.uk/48974/ http://eprints.nottingham.ac.uk/48974/ http://eprints.nottingham.ac.uk/48974/ http://eprints.nottingham.ac.uk/48974/1/F%20Paradisi%20Eng%20Substrate%202.pdf |