A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort

Objectives: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. Methods: Cognitive performan...

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Main Authors:	Koromina, Maria, Flitton, Miles, Mellor, Ian R., Knight, Helen M.
Format:	Article
Language:	English
Published:	Taylor & Francis 2018
Online Access:	http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/1/Submitted_Accepted_manuscriptSWBP-2017-0169.pdf

id	nottingham-48754
recordtype	eprints
spelling	nottingham-487542018-01-24T08:49:43Z http://eprints.nottingham.ac.uk/48754/ A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort Koromina, Maria Flitton, Miles Mellor, Ian R. Knight, Helen M. Objectives: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. Methods: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors. Performance in individuals homozygous for the insertion allele was compared to deletion carriers and analysis was adjusted for age of diagnosis, medication and clinical diagnosis. Results: Individuals with the GluK4 protective deletion allele performed significantly better in Spatial Working Memory compared to insertion homozygotes when adjusted for a clinical diagnosis. GluK4 deletion carriers who had a mental health problem (predominately depression) showed better performance in visuo-spatial ability and mental processing speed compared to individuals with mental health problems homozygous for the insertion. Conclusions: These findings of genotype-dependent cognitive enhancement across clinical groups support the potential clinical use of the GluK4 deletion allele in personalized medicine strategies and provide new insight into the relationship between genetic variation and mood disorders. Taylor & Francis 2018-01-11 Article PeerReviewed application/pdf en http://eprints.nottingham.ac.uk/48754/1/Submitted_Accepted_manuscriptSWBP-2017-0169.pdf Koromina, Maria and Flitton, Miles and Mellor, Ian R. and Knight, Helen M. (2018) A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort. World Journal of Biological Psychiatry . ISSN 1814-1412 http://www.tandfonline.com/doi/abs/10.1080/15622975.2017.1417637 doi:10.1080/15622975.2017.1417637 doi:10.1080/15622975.2017.1417637
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Objectives: Cognitive deficits are a common feature of neuropsychiatric disorders. We investigated the relationship between cognitive performance and a deletion allele within GluK4 protective against risk for bipolar disorder, in 1642 individuals from the TwinsUK study. Methods: Cognitive performance was assessed using the National Adult Reading Test, four CANTAB tests (Spatial Working Memory, Paired Associates Learning, Pattern Recognition Memory, and Reaction Time), and two Principal Component Analysis derived factors. Performance in individuals homozygous for the insertion allele was compared to deletion carriers and analysis was adjusted for age of diagnosis, medication and clinical diagnosis. Results: Individuals with the GluK4 protective deletion allele performed significantly better in Spatial Working Memory compared to insertion homozygotes when adjusted for a clinical diagnosis. GluK4 deletion carriers who had a mental health problem (predominately depression) showed better performance in visuo-spatial ability and mental processing speed compared to individuals with mental health problems homozygous for the insertion. Conclusions: These findings of genotype-dependent cognitive enhancement across clinical groups support the potential clinical use of the GluK4 deletion allele in personalized medicine strategies and provide new insight into the relationship between genetic variation and mood disorders.
format	Article
author	Koromina, Maria Flitton, Miles Mellor, Ian R. Knight, Helen M.
spellingShingle	Koromina, Maria Flitton, Miles Mellor, Ian R. Knight, Helen M. A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
author_facet	Koromina, Maria Flitton, Miles Mellor, Ian R. Knight, Helen M.
author_sort	Koromina, Maria
title	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
title_short	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
title_full	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
title_fullStr	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
title_full_unstemmed	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort
title_sort	kainate receptor gluk4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the twinsuk cohort
publisher	Taylor & Francis
publishDate	2018
url	http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/ http://eprints.nottingham.ac.uk/48754/1/Submitted_Accepted_manuscriptSWBP-2017-0169.pdf
first_indexed	2018-09-06T14:01:55Z
last_indexed	2018-09-06T14:01:55Z
_version_	1610867032337678336

A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort

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