Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the effects of nutrient “top-ups” in humans, and partic...

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Bibliographic Details
Main Authors: Mitchell, W. Kyle, Phillips, Bethan E., Hill, Ian, Greenhaff, Paul L., Lund, Jonathan N., Williams, John P., Rankin, Debbie, Wilkinson, Daniel J., Smith, Kenneth, Atherton, Philip J.
Format: Article
Language:English
Published: Portland Press 2017
Online Access:http://eprints.nottingham.ac.uk/47730/
http://eprints.nottingham.ac.uk/47730/
http://eprints.nottingham.ac.uk/47730/
http://eprints.nottingham.ac.uk/47730/1/CS-2017-1230_VoR1.pdf