Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe

Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP, suggesting the incidence of viral pneumonia may h...

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Main Authors:	Alimi, Y., Lim, W.S, Lansbury, Louise E., Leonardi-Bee, Jo, Nguyen-Van-Tam, Jonathan S.
Format:	Article
Language:	English
Published:	Elsevier 2017
Online Access:	http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/1/JCV%20R1%20FAM.pdf

id	nottingham-44522
recordtype	eprints
spelling	nottingham-445222018-08-05T04:30:13Z http://eprints.nottingham.ac.uk/44522/ Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe Alimi, Y. Lim, W.S Lansbury, Louise E. Leonardi-Bee, Jo Nguyen-Van-Tam, Jonathan S. Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP, suggesting the incidence of viral pneumonia may have been previously underestimated. We performed a systematic review and meta analysis to describe the overall identification of respiratory viruses in adult patients with CAP in Europe, following PRISMA guidelines (PROSPERO; CRD42016037233). We searched EMBASE, MEDLINE, CINAHL, WHOLIS, COCHRANE library and grey literature sources for relevant studies, and screened these against protocol eligibility criteria. Two researchers performed data extraction and risk of bias assessments, independently, using a piloted form. Results were synthesised narratively, and random effects meta-analyses performed to calculate pooled estimates of effect; heterogeneity was quantified using I2.Twenty-eight studies met inclusion criteria of which 21 were included in the primary meta-analysis. The pooled proportion of patients with identified respiratory viruses was 22.0% (95% CI: 18.0%-27.0%), rising to 29.0% (25.0%–34.0%) in studies where polymerase chain reaction (PCR) diagnostics were performed. Influenza virus was the most frequently detected virus in 9% (7%-12%) of adults with CAP. Respiratory viruses make a substantial contribution to the aetiology of CAP in adult patients in Europe; one or more respiratory viruses are detected in about one quarter of all cases. Elsevier 2017-10-31 Article PeerReviewed application/pdf en cc_by_nc_nd http://eprints.nottingham.ac.uk/44522/1/JCV%20R1%20FAM.pdf Alimi, Y. and Lim, W.S and Lansbury, Louise E. and Leonardi-Bee, Jo and Nguyen-Van-Tam, Jonathan S. (2017) Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe. Journal of Clinical Virology, 95 . pp. 26-35. ISSN 1873-5967 http://www.sciencedirect.com/science/article/pii/S1386653217302172 doi:10.1016/j.jcv.2017.07.019 doi:10.1016/j.jcv.2017.07.019
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Community-acquired pneumonia (CAP) is an important respiratory disease and the fifth leading cause of mortality in Europe. The development of molecular diagnostic tests has highlighted the contributions of respiratory viruses to the aetiology of CAP, suggesting the incidence of viral pneumonia may have been previously underestimated. We performed a systematic review and meta analysis to describe the overall identification of respiratory viruses in adult patients with CAP in Europe, following PRISMA guidelines (PROSPERO; CRD42016037233). We searched EMBASE, MEDLINE, CINAHL, WHOLIS, COCHRANE library and grey literature sources for relevant studies, and screened these against protocol eligibility criteria. Two researchers performed data extraction and risk of bias assessments, independently, using a piloted form. Results were synthesised narratively, and random effects meta-analyses performed to calculate pooled estimates of effect; heterogeneity was quantified using I2.Twenty-eight studies met inclusion criteria of which 21 were included in the primary meta-analysis. The pooled proportion of patients with identified respiratory viruses was 22.0% (95% CI: 18.0%-27.0%), rising to 29.0% (25.0%–34.0%) in studies where polymerase chain reaction (PCR) diagnostics were performed. Influenza virus was the most frequently detected virus in 9% (7%-12%) of adults with CAP. Respiratory viruses make a substantial contribution to the aetiology of CAP in adult patients in Europe; one or more respiratory viruses are detected in about one quarter of all cases.
format	Article
author	Alimi, Y. Lim, W.S Lansbury, Louise E. Leonardi-Bee, Jo Nguyen-Van-Tam, Jonathan S.
spellingShingle	Alimi, Y. Lim, W.S Lansbury, Louise E. Leonardi-Bee, Jo Nguyen-Van-Tam, Jonathan S. Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
author_facet	Alimi, Y. Lim, W.S Lansbury, Louise E. Leonardi-Bee, Jo Nguyen-Van-Tam, Jonathan S.
author_sort	Alimi, Y.
title	Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
title_short	Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
title_full	Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
title_fullStr	Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
title_full_unstemmed	Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe
title_sort	systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in europe
publisher	Elsevier
publishDate	2017
url	http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/ http://eprints.nottingham.ac.uk/44522/1/JCV%20R1%20FAM.pdf
first_indexed	2018-09-06T13:34:11Z
last_indexed	2018-09-06T13:34:11Z
_version_	1610865287041646592

Systematic review of respiratory viral pathogens identified in adults with community-acquired pneumonia in Europe

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