The heritability of multi-modal connectivity in human brain activity

Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determini...

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Main Authors:	Colclough, Giles L., Smith, Stephen M., Nichols, Tom E., Winkler, Anderson M., Sotiropoulos, Stamatios N., Glasser, Matthew F., Van Essen, David C., Woolrich, Mark W.
Format:	Article
Language:	English
Published:	eLife Sciences Publications 2017
Online Access:	http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/8/elife-20178-v3.pdf

id	nottingham-44464
recordtype	eprints
spelling	nottingham-444642018-01-12T04:42:04Z http://eprints.nottingham.ac.uk/44464/ The heritability of multi-modal connectivity in human brain activity Colclough, Giles L. Smith, Stephen M. Nichols, Tom E. Winkler, Anderson M. Sotiropoulos, Stamatios N. Glasser, Matthew F. Van Essen, David C. Woolrich, Mark W. Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity between 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, play a dominant role in determining the coupling of neuronal activity. eLife Sciences Publications 2017-07-26 Article PeerReviewed application/pdf en cc_by http://eprints.nottingham.ac.uk/44464/8/elife-20178-v3.pdf Colclough, Giles L. and Smith, Stephen M. and Nichols, Tom E. and Winkler, Anderson M. and Sotiropoulos, Stamatios N. and Glasser, Matthew F. and Van Essen, David C. and Woolrich, Mark W. (2017) The heritability of multi-modal connectivity in human brain activity. eLife, 6 . e20178. ISSN 2050-084X https://elifesciences.org/articles/20178 doi:10.7554/eLife.20178 doi:10.7554/eLife.20178
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Patterns of intrinsic human brain activity exhibit a profile of functional connectivity that is associated with behaviour and cognitive performance, and deteriorates with disease. This paper investigates the relative importance of genetic factors and the common environment between twins in determining this functional connectivity profile. Using functional magnetic resonance imaging (fMRI) on 820 subjects from the Human Connectome Project, and magnetoencephalographic (MEG) recordings from a subset, the heritability of connectivity between 39 cortical regions was estimated. On average over all connections, genes account for about 15% of the observed variance in fMRI connectivity (and about 10% in alpha-band and 20% in beta-band oscillatory power synchronisation), which substantially exceeds the contribution from the environment shared between twins. Therefore, insofar as twins share a common upbringing, it appears that genes, rather than the developmental environment, play a dominant role in determining the coupling of neuronal activity.
format	Article
author	Colclough, Giles L. Smith, Stephen M. Nichols, Tom E. Winkler, Anderson M. Sotiropoulos, Stamatios N. Glasser, Matthew F. Van Essen, David C. Woolrich, Mark W.
spellingShingle	Colclough, Giles L. Smith, Stephen M. Nichols, Tom E. Winkler, Anderson M. Sotiropoulos, Stamatios N. Glasser, Matthew F. Van Essen, David C. Woolrich, Mark W. The heritability of multi-modal connectivity in human brain activity
author_facet	Colclough, Giles L. Smith, Stephen M. Nichols, Tom E. Winkler, Anderson M. Sotiropoulos, Stamatios N. Glasser, Matthew F. Van Essen, David C. Woolrich, Mark W.
author_sort	Colclough, Giles L.
title	The heritability of multi-modal connectivity in human brain activity
title_short	The heritability of multi-modal connectivity in human brain activity
title_full	The heritability of multi-modal connectivity in human brain activity
title_fullStr	The heritability of multi-modal connectivity in human brain activity
title_full_unstemmed	The heritability of multi-modal connectivity in human brain activity
title_sort	heritability of multi-modal connectivity in human brain activity
publisher	eLife Sciences Publications
publishDate	2017
url	http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/ http://eprints.nottingham.ac.uk/44464/8/elife-20178-v3.pdf
first_indexed	2018-09-06T13:33:46Z
last_indexed	2018-09-06T13:33:46Z
_version_	1610865260614385664

The heritability of multi-modal connectivity in human brain activity

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