Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers
Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO2A, DNA-PKcs, Ku70/Ku80), nucleotide excision repa...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for Cancer Research
2017
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| Online Access: | http://eprints.nottingham.ac.uk/43070/ http://eprints.nottingham.ac.uk/43070/ http://eprints.nottingham.ac.uk/43070/ http://eprints.nottingham.ac.uk/43070/9/Tumor%20CIR_2017.pdf |