Structural brain correlates of adolescent resilience

Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated...

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Main Authors:	Burt, Keith B., Whelan, Robert, Conrod, Patricia J., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Fauth-Bühler, Mira, Flor, Herta, Galinowski, André, Gallinat, Juergen, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mann, Karl, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomas, Pausova, Zdenka, Poustka, Luise, Rietschel, Marcella, Robbins, Trevor W., Smolka, Michael N., Ströhle, Andreas, Schumann, Gunter, Garavan, Hugh
Format:	Article
Language:	English
Published:	Wiley 2016
Online Access:	http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/1/Burt%20et%20al%20adolescent%20resilience%20-%20final%20including%20figure%20and%20supplement.pdf

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spelling	nottingham-426362018-07-02T09:12:45Z http://eprints.nottingham.ac.uk/42636/ Structural brain correlates of adolescent resilience Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity. Wiley 2016-11-30 Article PeerReviewed application/pdf en http://eprints.nottingham.ac.uk/42636/1/Burt%20et%20al%20adolescent%20resilience%20-%20final%20including%20figure%20and%20supplement.pdf Burt, Keith B. and Whelan, Robert and Conrod, Patricia J. and Banaschewski, Tobias and Barker, Gareth J. and Bokde, Arun L.W. and Bromberg, Uli and Büchel, Christian and Fauth-Bühler, Mira and Flor, Herta and Galinowski, André and Gallinat, Juergen and Gowland, Penny and Heinz, Andreas and Ittermann, Bernd and Mann, Karl and Nees, Frauke and Papadopoulos-Orfanos, Dimitri and Paus, Tomas and Pausova, Zdenka and Poustka, Luise and Rietschel, Marcella and Robbins, Trevor W. and Smolka, Michael N. and Ströhle, Andreas and Schumann, Gunter and Garavan, Hugh (2016) Structural brain correlates of adolescent resilience. Journal of Child Psychology and Psychiatry, 57 (11). pp. 1287-1296. ISSN 1469-7610 http://onlinelibrary.wiley.com/doi/10.1111/jcpp.12552/abstract doi:10.1111/jcpp.12552 doi:10.1111/jcpp.12552
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Background Despite calls for integration of neurobiological methods into research on youth resilience (high competence despite high adversity), we know little about structural brain correlates of resilient functioning. The aim of the current study was to test for brain regions uniquely associated with positive functioning in the context of adversity, using detailed phenotypic classification. Methods 1,870 European adolescents (Mage = 14.56 years, SDage = 0.44 years, 51.5% female) underwent MRI scanning and completed behavioral and psychological measures of stressful life events, academic competence, social competence, rule-abiding conduct, personality, and alcohol use. Results The interaction of competence and adversity identified two regions centered on the right middle and superior frontal gyri; grey matter volumes in these regions were larger in adolescents experiencing adversity who showed positive adaptation. Differences in these regions among competence/adversity subgroups were maintained after controlling for several covariates and were robust to alternative operationalization decisions for key constructs. Conclusions We demonstrate structural brain correlates of adolescent resilience, and suggest that right prefrontal structures are implicated in adaptive functioning for youth who have experienced adversity.
format	Article
author	Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh
spellingShingle	Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh Structural brain correlates of adolescent resilience
author_facet	Burt, Keith B. Whelan, Robert Conrod, Patricia J. Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Fauth-Bühler, Mira Flor, Herta Galinowski, André Gallinat, Juergen Gowland, Penny Heinz, Andreas Ittermann, Bernd Mann, Karl Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomas Pausova, Zdenka Poustka, Luise Rietschel, Marcella Robbins, Trevor W. Smolka, Michael N. Ströhle, Andreas Schumann, Gunter Garavan, Hugh
author_sort	Burt, Keith B.
title	Structural brain correlates of adolescent resilience
title_short	Structural brain correlates of adolescent resilience
title_full	Structural brain correlates of adolescent resilience
title_fullStr	Structural brain correlates of adolescent resilience
title_full_unstemmed	Structural brain correlates of adolescent resilience
title_sort	structural brain correlates of adolescent resilience
publisher	Wiley
publishDate	2016
url	http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/ http://eprints.nottingham.ac.uk/42636/1/Burt%20et%20al%20adolescent%20resilience%20-%20final%20including%20figure%20and%20supplement.pdf
first_indexed	2018-09-06T13:21:21Z
last_indexed	2018-09-06T13:21:21Z
_version_	1610864479421071360

Structural brain correlates of adolescent resilience

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