Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition
Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and PhTX-12, were developed. Previous work showed a 22-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016
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| Online Access: | http://eprints.nottingham.ac.uk/40074/ http://eprints.nottingham.ac.uk/40074/ http://eprints.nottingham.ac.uk/40074/ http://eprints.nottingham.ac.uk/40074/1/Kachel_et_al-2016-Scientific_Reports.pdf |