Primordial germ cells: the first cell lineage or the last cells standing?
Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this manner. The ‘last cell standing’ model describes...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Company of Biologists
2015
|
| Online Access: | http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/1/Development-2015-Johnson-2730-9.pdf |
| id |
nottingham-37066 |
|---|---|
| recordtype |
eprints |
| spelling |
nottingham-370662018-07-02T09:08:12Z http://eprints.nottingham.ac.uk/37066/ Primordial germ cells: the first cell lineage or the last cells standing? Johnson, Andrew D. Alberio, Ramiro Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this manner. The ‘last cell standing’ model describes primordial germ cell (PGC) development in axolotls, in which PGCs are maintained by an extracellular signalling niche, and germ line commitment occurs after gastrulation. Here, we propose that this ‘stochastic’ mode of PGC specification is conserved in vertebrates, including non-rodent mammals. We postulate that early germ line segregation liberates genetic regulatory networks for somatic development to evolve, and that it therefore emerged repeatedly in the animal kingdom in response to natural selection. Company of Biologists 2015-08-18 Article PeerReviewed application/pdf en cc_by http://eprints.nottingham.ac.uk/37066/1/Development-2015-Johnson-2730-9.pdf Johnson, Andrew D. and Alberio, Ramiro (2015) Primordial germ cells: the first cell lineage or the last cells standing? Development, 142 . pp. 2730-2739. ISSN 1477-9129 http://dev.biologists.org/content/142/16/2730 doi: 10.1242/dev.113993 doi: 10.1242/dev.113993 |
| repository_type |
Digital Repository |
| institution_category |
Local University |
| institution |
University of Nottingham Malaysia Campus |
| building |
Nottingham Research Data Repository |
| collection |
Online Access |
| language |
English |
| description |
Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this manner. The ‘last cell standing’ model describes primordial germ cell (PGC) development in axolotls, in which PGCs are maintained by an extracellular signalling niche, and germ line commitment occurs after gastrulation. Here, we propose that this ‘stochastic’ mode of PGC specification is conserved in vertebrates, including non-rodent mammals. We postulate that early germ line segregation liberates genetic regulatory networks for somatic development to evolve, and that it therefore emerged repeatedly in the animal kingdom in response to natural selection. |
| format |
Article |
| author |
Johnson, Andrew D. Alberio, Ramiro |
| spellingShingle |
Johnson, Andrew D. Alberio, Ramiro Primordial germ cells: the first cell lineage or the last cells standing? |
| author_facet |
Johnson, Andrew D. Alberio, Ramiro |
| author_sort |
Johnson, Andrew D. |
| title |
Primordial germ cells: the first cell lineage or the last cells standing? |
| title_short |
Primordial germ cells: the first cell lineage or the last cells standing? |
| title_full |
Primordial germ cells: the first cell lineage or the last cells standing? |
| title_fullStr |
Primordial germ cells: the first cell lineage or the last cells standing? |
| title_full_unstemmed |
Primordial germ cells: the first cell lineage or the last cells standing? |
| title_sort |
primordial germ cells: the first cell lineage or the last cells standing? |
| publisher |
Company of Biologists |
| publishDate |
2015 |
| url |
http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/ http://eprints.nottingham.ac.uk/37066/1/Development-2015-Johnson-2730-9.pdf |
| first_indexed |
2018-09-06T12:44:52Z |
| last_indexed |
2018-09-06T12:44:52Z |
| _version_ |
1610862184135393280 |