Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex

Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL)...

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Main Authors:	Fenton, G.E., Halliday, D.M., Mason, Rob, Bredy, Timothy W., Stevenson, Carl W.
Format:	Article
Language:	English
Published:	Elsevier 2016
Online Access:	http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/8/Fenton%20et%20al%202016%20in%20press.pdf

id	nottingham-37029
recordtype	eprints
spelling	nottingham-370292018-06-26T12:36:17Z http://eprints.nottingham.ac.uk/37029/ Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction. Elsevier 2016-11 Article PeerReviewed application/pdf en cc_by_nc_nd http://eprints.nottingham.ac.uk/37029/8/Fenton%20et%20al%202016%20in%20press.pdf Fenton, G.E. and Halliday, D.M. and Mason, Rob and Bredy, Timothy W. and Stevenson, Carl W. (2016) Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex. Neurobiology of Learning and Memory, 135 . pp. 66-72. ISSN 1095-9564 http://www.sciencedirect.com/science/article/pii/S1074742716300934 doi: 10.1016/j.nlm.2016.06.019 doi: 10.1016/j.nlm.2016.06.019
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female rats. Emerging evidence indicates that gamma oscillations in mPFC are also implicated in the expression and extinction of learned fear. Therefore we re-examined our in vivo electrophysiology data and found that females showed persistent PL gamma activation during extinction and a failure of IL gamma activation during extinction recall. Altered prefrontal gamma oscillations thus accompany sex differences in learned fear expression and its extinction. These findings are relevant for understanding the neural basis of post-traumatic stress disorder, which is more prevalent in women and involves impaired extinction and mPFC dysfunction.
format	Article
author	Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W.
spellingShingle	Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W. Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
author_facet	Fenton, G.E. Halliday, D.M. Mason, Rob Bredy, Timothy W. Stevenson, Carl W.
author_sort	Fenton, G.E.
title	Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
title_short	Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
title_full	Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
title_fullStr	Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
title_full_unstemmed	Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
title_sort	sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex
publisher	Elsevier
publishDate	2016
url	http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/ http://eprints.nottingham.ac.uk/37029/8/Fenton%20et%20al%202016%20in%20press.pdf
first_indexed	2018-09-06T12:44:37Z
last_indexed	2018-09-06T12:44:37Z
_version_	1610862168620662784

Sex differences in learned fear expression and extinction involve altered gamma oscillations in medial prefrontal cortex

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