An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids

We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission...

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Main Authors:	Amey, Joanna S., O'Reilly, Andrias O., Burton, Mark J., Puinean, Alin M., Mellor, Ian R., Duce, Ian R., Field, Linda M., Wallace, B.A., Williamson, Martin S., Davies, T.G. Emyr
Format:	Article
Language:	English
Published:	Wiley 2015
Online Access:	http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/1/Amey_et_al-2015-FEBS_Letters.pdf

id	nottingham-34979
recordtype	eprints
spelling	nottingham-349792017-10-14T08:45:02Z http://eprints.nottingham.ac.uk/34979/ An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels. Wiley 2015-02-27 Article PeerReviewed application/pdf en cc_by http://eprints.nottingham.ac.uk/34979/1/Amey_et_al-2015-FEBS_Letters.pdf Amey, Joanna S. and O'Reilly, Andrias O. and Burton, Mark J. and Puinean, Alin M. and Mellor, Ian R. and Duce, Ian R. and Field, Linda M. and Wallace, B.A. and Williamson, Martin S. and Davies, T.G. Emyr (2015) An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids. FEBS Letters, 589 (5). pp. 598-607. ISSN 1873-3468 http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2015.01.020/abstract doi:10.1016/j.febslet.2015.01.020 doi:10.1016/j.febslet.2015.01.020
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels.
format	Article
author	Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr
spellingShingle	Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
author_facet	Amey, Joanna S. O'Reilly, Andrias O. Burton, Mark J. Puinean, Alin M. Mellor, Ian R. Duce, Ian R. Field, Linda M. Wallace, B.A. Williamson, Martin S. Davies, T.G. Emyr
author_sort	Amey, Joanna S.
title	An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
title_short	An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
title_full	An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
title_fullStr	An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
title_full_unstemmed	An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
title_sort	evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids
publisher	Wiley
publishDate	2015
url	http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/ http://eprints.nottingham.ac.uk/34979/1/Amey_et_al-2015-FEBS_Letters.pdf
first_indexed	2018-09-06T12:32:14Z
last_indexed	2018-09-06T12:32:14Z
_version_	1610861389905133568

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids

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