The multidrug transporter ABCG2: still more questions than answers

ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in chemotherapy, but is also one of the more perplexi...

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Main Authors:	Horsey, Aaron J., Cox, Megan H., Sarwat, Sunehera, Kerr, Ian D.
Format:	Article
Language:	English
Published:	Portland Press Ltd 2016
Online Access:	http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/1/Horsey_2016_BiochemSocTrans.pdf

id	nottingham-34238
recordtype	eprints
spelling	nottingham-342382017-10-13T21:09:55Z http://eprints.nottingham.ac.uk/34238/ The multidrug transporter ABCG2: still more questions than answers Horsey, Aaron J. Cox, Megan H. Sarwat, Sunehera Kerr, Ian D. ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in chemotherapy, but is also one of the more perplexing phenomena in transporter biochemistry. Since its discovery in the last decade of the 20th century much has been revealed about ABCG2's localization, physiological function and its broad substrate range. There have also been many investigations of its structure and molecular mechanism. In this mini review article we take a Rumsfeldian approach to ABCG2 and essentially ask what we do know about this transporter, and what we will need to know about this transporter if we wish to use modulation of ABCG2 activity as a therapeutic approach. Portland Press Ltd 2016-06-15 Article PeerReviewed application/pdf en cc_by http://eprints.nottingham.ac.uk/34238/1/Horsey_2016_BiochemSocTrans.pdf Horsey, Aaron J. and Cox, Megan H. and Sarwat, Sunehera and Kerr, Ian D. (2016) The multidrug transporter ABCG2: still more questions than answers. Biochemical Society Transactions, 44 (3). pp. 824-830. ISSN 0300-5127 http://www.biochemsoctrans.org/content/44/3/824 doi:10.1042/BST20160014 doi:10.1042/BST20160014
repository_type	Digital Repository
institution_category	Local University
institution	University of Nottingham Malaysia Campus
building	Nottingham Research Data Repository
collection	Online Access
language	English
description	ABCG2 is one of at least three human ATP binding cassette (ABC) transporters which can facilitate the export from cells of a wide range of chemically unrelated drug molecules. This capacity for multidrug transport is not only a confounding factor in chemotherapy, but is also one of the more perplexing phenomena in transporter biochemistry. Since its discovery in the last decade of the 20th century much has been revealed about ABCG2's localization, physiological function and its broad substrate range. There have also been many investigations of its structure and molecular mechanism. In this mini review article we take a Rumsfeldian approach to ABCG2 and essentially ask what we do know about this transporter, and what we will need to know about this transporter if we wish to use modulation of ABCG2 activity as a therapeutic approach.
format	Article
author	Horsey, Aaron J. Cox, Megan H. Sarwat, Sunehera Kerr, Ian D.
spellingShingle	Horsey, Aaron J. Cox, Megan H. Sarwat, Sunehera Kerr, Ian D. The multidrug transporter ABCG2: still more questions than answers
author_facet	Horsey, Aaron J. Cox, Megan H. Sarwat, Sunehera Kerr, Ian D.
author_sort	Horsey, Aaron J.
title	The multidrug transporter ABCG2: still more questions than answers
title_short	The multidrug transporter ABCG2: still more questions than answers
title_full	The multidrug transporter ABCG2: still more questions than answers
title_fullStr	The multidrug transporter ABCG2: still more questions than answers
title_full_unstemmed	The multidrug transporter ABCG2: still more questions than answers
title_sort	multidrug transporter abcg2: still more questions than answers
publisher	Portland Press Ltd
publishDate	2016
url	http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/ http://eprints.nottingham.ac.uk/34238/1/Horsey_2016_BiochemSocTrans.pdf
first_indexed	2018-09-06T12:26:49Z
last_indexed	2018-09-06T12:26:49Z
_version_	1610861049052921856

The multidrug transporter ABCG2: still more questions than answers

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