Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Background Several regions of the genome have shown to be associated with COPD in genome-wide association studies of common variants. Objective To determine rare and potentially functional single nucleotide polymorphisms (SNPs) associated with the risk of COPD and severity of airflow lim...

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Main Authors: Jackson, Victoria E., Ntalla, Ioanna, Sayers, Ian, Morris, Richard, Whincup, Peter, Casas, Juan-Pablo, Amuzu, Antoinette, Choi, Minkyoung, Dale, Caroline, Kumari, Meena, Engmann, Jorgen, Kalsheker, Noor, Chappell, Sally, Guetta-Baranes, Tamar, McKeever, Tricia M., Palmer, Colin N.A., Tavendale, Roger, Holloway, John W., Sayer, Avan A., Dennison, Elaine M., Cooper, Cyrus, Bafadhel, Mona, Barker, Bethan, Brightling, Chris, Bolton, Charlotte E., John, Michelle E., Parker, Stuart G., Moffat, Miriam F., Wardlaw, Andrew J., Connolly, Martin J., Porteous, David J., Smith, Blair H., Padmanabhan, Sandosh, Hocking, Lynne, Stirrups, Kathleen E., Deloukas, Panos, Strachan, David P., Hall, Ian P., Tobin, Martin D., Wain, Louise V.
Format: Article
Language:English
English
Published: BMJ Publishing Group 2016
Online Access:http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/2/Jackson%20Thorax%202016%20suppl.pdf
http://eprints.nottingham.ac.uk/32631/76/Thorax-2016-Jackson-thoraxjnl-2015-207876.pdf

Internet

http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/
http://eprints.nottingham.ac.uk/32631/2/Jackson%20Thorax%202016%20suppl.pdf
http://eprints.nottingham.ac.uk/32631/76/Thorax-2016-Jackson-thoraxjnl-2015-207876.pdf

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