Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor
Established therapy in Alzheimer’s disease involves potentiation of the endogenous orthosteric ligand, acetylcholine, at the M1 muscarinic receptors found in higher concentrations in the cortex and hippocampus. Adverse effects, due to indiscriminate activation of other muscarinic receptor subtypes,...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2013
|
| Online Access: | http://eprints.nottingham.ac.uk/30413/ http://eprints.nottingham.ac.uk/30413/ http://eprints.nottingham.ac.uk/30413/ http://eprints.nottingham.ac.uk/30413/1/jm-2013-00540b.R1%20-%20JMC%2056%2812%29%202013%205151.pdf |